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Lesion studies in rats show altered in vitro glucose carbon incorporation into several tissue fractions both a few days, and one mo after lesion production.

Several of these changes may be due to the reduced food intake, others appear to be due to a “true” lesion effect.

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Rats with LHA lesions regulate their body weight set point in a primary manner and not because of destruction of a “feeding center”. In the early stages of the syndrome, catabolism and running activity are enhanced, and so is the activity of the sympathetic nervous system (SNS) as shown by increased norepinephrine excretion that normalizes one mo later.

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