In the same year, they starred as Lemuel Gulliver and his wife in an acclaimed television miniseries of Gulliver's Travels.Danson went on to star in the successful CBS sitcom Becker (produced by Paramount Television, which also produced Cheers), which ran from 1998 to 2004. He reprised his role of Sam Malone in a second-season episode of Frasier and voiced him in The Simpsons episode "Fear of Flying".It won four Emmy Awards for Outstanding Comedy Series and a Golden Globe for Best Series – Musical or Comedy.The show ran from 1982 to 1993, with Danson receiving 11 consecutive Emmy nominations and nine Golden Globe nominations, ultimately winning two Emmys and two Golden Globes.
Although he was best known for his work in comedy, he also appeared in an acclaimed drama, Something About Amelia, about a family devastated by the repercussions of incest, which co-starred his later co-star on Damages, Glenn Close.
In July 2011 it was announced that Danson would star in the CBS police drama CSI: Crime Scene Investigation. Tony Shalhoub, Robin Williams and John Lithgow were also considered for the role. His most notable film appearances were in Three Men and a Baby with Tom Selleck and Steve Guttenberg, its sequel Three Men and a Little Lady and Cousins with Isabella Rossellini.
Following the cancellation of CSI: Crime Scene Investigation, it was announced that his character D. Russell would make a move over to the third spinoff show CSI: Cyber in the second season. He also appeared in The Onion Field (his first film, as the bagpipe playing Officer Ian Campbell), Creepshow, Body Heat, Little Treasure, Just Between Friends, A Fine Mess, Dad, Made in America, Getting Even with Dad and Saving Private Ryan.
In 1999 Danson was presented with a star on Hollywood's Walk of Fame.
Danson returned to series television in the fall of 2006, playing a psychiatrist in the ABC sitcom Help Me Help You, which was canceled at midseason due to low ratings.
In 2002, TV Guide named Cheers the 18th Greatest Show of All Time.